All regions are now in the “red zone” – the highest tier of restrictions – as the country battles the third wave, with about 20,000 new cases a day.
Non-essential movement is banned, but people are allowed to have an Easter meal in their homes with two others.
Churches are also open, but worshippers are being told to attend services within their own regions.
For the second year, Pope Francis will deliver his Easter message to an empty St Peter’s Square.
Following the holiday weekend, different regions will then remain in either “orange zone” or “red zone” restrictions until the end of the month.
Italy’s restrictions come as countries across Europe try to control a surge in cases of the virus while struggling with a delayed vaccine rollout.
More than 110,328 people in total have died of the coronavirus in Italy, and there have been 3.6 million confirmed infections.